WebCyclic GMP-AMP synthase (cGAS) is a major sensor of cytosolic DNA from invading pathogens and damaged cellular organelles. Activation of cGAS promotes liquid-like phase separation and formation of membraneless cytoplasmic structures. WebApr 15, 2024 · Similarly, several sensors of nucleic acids that initiate innate immunity, such as cGAS-STING proteins and RIG-like and NOD-like receptors, were also downregulated (Fig. 3e).
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS ...
WebMay 27, 2024 · RNA-seq analysis and fluorescence microscopic imaging were performed … WebApr 10, 2024 · With further aging, all KO mice developed heart failure (HF) (6M male: WT 50 ± 15, KO 27 ± 12 %FAC, p < 0.001) associated with increased mortality. RNA-Seq analysis revealed deregulated gene expression of metabolic and sarcomeric genes as well as genes involved in Ca2+ homeostasis and electrical conduction. how to help an overprotective dog
P2rx1 deficiency alleviates acetaminophen-induced acute liver …
WebJul 18, 2024 · A signaling pathway in eukaryotes known as cGAS–STING recognizes the presence of cytosolic DNA, which alerts the immune system to viral infection or cellular damage. However, the majority of DNA viruses direct their genomic DNA into nuclei, suggesting that nuclear-specific sensing is also needed. L. WebMay 5, 2024 · Hepatic RNA-seq analysis of patients with a wide spectrum of ALD revealed that expression of the cGAS-IRF3 pathway correlated positively with disease severity. Alcohol-fed mice demonstrated increased hepatic expression of the cGAS-IRF3 pathway. ... Consistent with this conclusion, we found that alcohol-fed cGAS KO mice had … WebIn this study, analyzing genotype and haplotype data from the 1000 Genomes Project, we found that the R71H-G230A-R293Q (HAQ) MPYS allele frequency increased 57-fold in East Asians compared with... join clear webfocus